p31comet-Induced Cell Death Is Mediated by Binding and Inactivation of Mad2.
Mad2, a key telemarkskongen flue component of the spindle checkpoint, is closely associated with chromosomal instability and poor prognosis in cancer.p31comet is a Mad2-interacting protein that serves as a spindle checkpoint silencer at mitosis.In this study, we showed that p31comet-induced apoptosis and senescence occur via counteraction of Mad2 a